選單

2011年12月27日 星期二

08、生長因子與表皮層毛囊的相互關係

生長因子與表皮層毛囊的相互關係
 
Takakura 等人顯示血小板衍生生長因子(PDGF)信號參與了表皮層毛囊之交互作用,以及皮膚間質細胞間交互作用。這兩者各別皆是毛髮通道形成及皮膚間質細胞成長不可或缺的 Takakura, N., et al. Involvement of platelet derived growth factor receptor-a in hair canal formation. J of investigative Derm. 1996; 107:770-777.

2001 , Yano 等人辨識出血管內皮生長因子(VEGF)是毛囊生長及週期巡迴的主要調節物質,因而首次証明毛囊血管活化可以促進毛髮生長、增加毛囊及毛髮尺寸。 Yano, Brown, and M. Detmar. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest. 2001; 107(4):409-417.

These results identify VEGF as a major mediator of hair follicle growth and cycling and provide the first direct evidence that
improved follicle vascularization promotes hair growth and increases hair follicle and hair size.

這些結果顯示血管內皮生長因子是毛髮毛囊生長及週期的主要調節物質,並且是首次證明毛囊血管活化改善、有促進毛髮生長、增加毛囊尺寸的效果。

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